Posted On 2023-05-23

Guest Editor: Dr. Ian James Martins

Ph.D., D.Sc and Dr.Med, Doctrin de Science, Honoris Causa. 




Dear Colleagues,

Age-related diseases are becoming a major concern as the world’s population grows older due to advances in technology, health, and nutrition. The process of aging is determined by various genetic and environmental factors with epigenetic alterations now considered as a major defect in insulin signaling and the global chronic disease epidemic. Nutritional interventions are now critical to reverse that aging process with the activation of anti-aging genes that prevent mitophagy and programmed cell death. The global diabetes epidemic is now closely linked to accelerated aging and nutritional interventions reverse the aging process and enhance insulin signaling that stabilizes the various organ diseases. The use of anti-aging drugs (metformin, acarbose, canagliflozin as well as others) has now become of importance to age-related diseases with the use of these drugs to reverse transcriptional dysregulation, subcellular changes, and membrane alterations in diabetes and Alzheimer’s disease. Anti-aging drugs such as metformin and rapamycin are now important to activate anti-aging genes and reverse the aging process that is connected to insulin signaling, neurodegeneration, and global chronic disease. The use of drugs that target insulin signaling with nutritional interventions increases longevity by reducing oxidative stress and targeted insulin signaling with increased lifespan in animals and man.

Dr. Ian James Martins
Guest Editor


Completion Date

February 1st, 2023



Elizabeth Rhea and William Allen Banks, VA Puget Sound Healthcare System, University of Washington, Seattle, WA, USA.
Adam B. Salmon, University of Texas Health Science Center at San Antonio, Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.
Albert Augustin, Klinikum Karlsruhe, Augenklin, Moltkestr 90, D-76133 Karlsruhe, Germany.
Nurten Arslan, Faculty of Health Sciences, Erzincan University, Erzincan, Turkey.

Table of Contents


William A Banks, Cassidy Noonan, Elizabeth M Rhea
Received: Thursday, September 1, 2022      Published: Tuesday, May 23, 2023
Albert J Augustin, Jenny Atorf
Received: Wednesday, August 24, 2022      Published: Tuesday, May 23, 2023

Subscribe to receive issue release notifications
and newsletters from journals