Posted On 2022-09-19


Guest Editor: Asso. Prof. James M. Harper


Department of Biological Sciences, Sam Houston State University, Huntsville TX 77340, Texas, USA.







The maintenance of normal physiological function is dependent on proper energetic balance. A significant alteration of energy regulation is tied to the decline in physiological function seen with increasing age in organismal models of aging. Experimental interventions that slow the aging process, such as caloric restriction, result in significant changes in metabolic function and cellular energetics, with similar effects also observed in many of the genetic models of delayed aging, especially those involving the insulin/insulin-like growth factor axis. There is increasing evidence that the maintaining energy metabolism in older individuals is an important mediator of longevity and health span.


Manuscript Submission Information

Manuscripts should be submitted online at through the online submission system. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, Review articles as well as Therapeutic Brief are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. APT is an international peer-reviewed open access quarterly journal published by ANT.

Please visit the Instructions for Authors page before submitting a manuscript. Considering limited grants for some researchers, Dr. James M. Harper and the editorial office made the decision that Article Processing Charges will be fully exempted, which means that there is NOT any manuscript processing or publication fees for your article once accepted after standard peer-review.


Submission Deadline

December 31st, 2023



Charles V Mobbs, The Graduate School of the Icahn School of Medicine at Mount Sinai, New York, NY 10028, USA.

Harish Rangareddy, Haveri Institute of Medical Sciences, Haveri, India.

Takashi Nakagawa, Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Japan.




June Wong, Managing Editor,
Alan Zhou, Assistant Editor,


Updated on December 12, 2022

Table of Contents


Harish Rangareddy, Venkateshappa Chikkanarayanappa, Rajhi Hayfa, Ashakiran Srinivasaiah, Reshma Devarajachar
Received: Friday, February 2, 2024      Published: Thursday, March 28, 2024

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