• 环保意识的提升促使消费者更倾向于购买可持续产品。
  • 随着技术的发展,智能家居和自动化生活正在成为现实。
  • 海洋塑料污染问题成为全球环境保护的重要议题。
  • 智能家居设备的发展正在改变人们的生活方式。
  • 在线教育平台的兴起挑战了传统教育模式和学习习惯。
  • 隐私保护和数据安全在数字化时代变得更加重要。
  • 全球变暖问题促使各国政府加大力度推动绿色能源的发展。
  • 随着环保意识的提高,可持续消费成为新的消费趋势。
  • 随着全球健康危机的持续,公共卫生体系的完善成为紧迫议题。
  • 随着全球人口老龄化,养老服务和健康管理成为新的社会需求。
  • 随着技术的发展,智能家居设备正在改变日常生活。
  • 社交媒体的算法调整引发了公众对隐私保护的担忧。
  • 社交媒体的算法透明度问题引起了公众的广泛关注。
  • 自动化和机器人技术在提高制造业效率和安全性方面发挥着关键作用。
  • 全球健康危机加速了医疗保健行业的数字化转型。
  • 随着技术的发展,智能家居和自动化生活正在成为现实。
  • 电子商务的快速发展对传统零售业造成了巨大冲击。
  • 自动化和机器人技术在制造业中的应用提高了生产效率和安全性。
  • 随着人们对健康意识的提高,健康食品和生活方式受到更多关注。
  • 生物技术在医药领域的应用为治疗复杂疾病提供了新的可能性。
  • 全球化背景下,文化交流和融合成为常态。
  • 随着人口老龄化的加剧,养老服务和健康管理需求日益增长。
  • 全球疫情的逐渐缓解使得经济复苏成为各国政府的首要任务。
  • 电子商务的快速发展改变了消费者的购物习惯。
  • 随着人口老龄化,对老年护理和健康服务的需求不断增长。
  • Physical performance is enhanced in old mice fed a short term diet medicated with rapamycin, acarbose, and phenylbutyrate | Ellis | Aging Pathobiology and Therapeutics

    Physical performance is enhanced in old mice fed a short term diet medicated with rapamycin, acarbose, and phenylbutyrate

    Megan Ellis, Warren Ladiges, Zhou Jiang

    Abstract


    Loss of physical performance, as seen in humans by decreased grip strength and overall physical fitness, is generally accepted to be a consequence of aging. Treatments to delay or reduce these changes or increase resilience to them are generally not available. In this preliminary study, 20-month-old male and female C57BL/6 mice were given either a standard mouse diet or a formulated mouse diet containing rapamycin (14 ppm), acarbose (1000 ppm), and phenylbutyrate (1000 ppm), or a diet containing one half dose of each drug, for 3 months. At the end of the study, performance on a rotarod and grip strength test was compared. In general, mice fed the full dose drug cocktail diet performed better on these assays, with significant improvements in rotarod performance in females fed the full dose cocktail and in grip strength in males fed the full dose cocktail, and females fed the low dose cocktail. These observations provide support for the concept that short term treatment with a cocktail of drugs that targets multiple aging pathways can increase resilience to aging, and suggests that this prototype cocktail could be part of a clinical therapeutic strategy for delaying age-related loss of physical performance in people.

    Keywords: Healthy aging, physical performance, aging processes, anti-aging drug cocktail, rapamycin, acarbose, phenylbutyrate, aging mice




    Subscribe to receive issue release notifications
    and newsletters from journals