Targeting metabolism through exercise and nutrition to rejuvenate an aging immune system

Abstract

Dysregulated metabolism is a hallmark of the aging process. Immune function is tightly controlled by cellular metabolism, and emerging evidence indicates that aged immune cells have alterations in metabolism that may promote aging-related disease. Lifestyle interventions including diet and exercise are potent strategies for targeting metabolic dysfunction in aging, but to date, only a few studies have examined the ability of exercise or diet to regulate immunometabolism, despite their well-known positive effects on healthspan and lifespan. Utilizing lifestyle modification as precision medicine to target age-related diseases through modulating immunometabolism is promising, but a great deal of work remains.

Keywords: Immunometabolism, exercise, diet, inflammaging, immunosenescence