Stricter definitions of myeloid senescence are needed

Abstract

Cellular senescence is a state of irreversible cell cycle arrest that is associated with age-related diseases. There is considerable interest in studying senescence in immune cells such as macrophages. However, current popular markers of cellular senescence overlap substantially with cellular programs induced in macrophages and related cells during acute inflammation responses, raising questions about the degree to which the current literature truly reflects senescence in the innate immune system.

Keywords: Senescence, macrophage, monocyte, dendritic cell, immune aging