Aging Pathobiology and Therapeutics

Aging Pathobiology and Therapeutics (APT, Online ISSN 2690-1803) is open access, peer-reviewed, interdisciplinary journal available online. The journal quarterly publishes research articles, reviews, editorials, case reports, opinions, letters, abstracts, and therapeutic drug briefs relating to research on the pathobiology of aging and age-related diseases. The journal aims to provide a platform for scientists and academicians worldwide to promote, share, and discuss various new issues and developments in different areas of the pathobiology of aging and age-related diseases. Scholars from the disciplines of geriatrics, gerontology, physiology, pathology, pharmacology, toxicology, biology, neuropsychology, psychology, nursing, epidemiology, and genetics are encouraged to contribute articles to the journal.

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Review Development of dietary supplements to eliminate the atherogenicity of low-density lipoprotein Tatyana Ivanovna Kovyanova, Vasily Petrovich Karagodin, Daria Dmitryevna Borodko, Ulyana Vyacheslavovna Rozhkova, Stanislav Anatolievich Antonov, Aleksandra Sergeevna Utkina, Galina Alexandrovna Chizhikova Published: Friday, September 11, 2026

Research Article Deciphering the action of indole analogues on selected targets for neuroprotection in Alzheimer’s disease. Network pharmacology, in silico, and in vitro approaches Manas kumar Gedla, Ramanathan Muthiah Published: Friday, September 11, 2026

Review Molecular and cellular mechanisms underlying Alzheimer’s disease: an integrated review Mohammad Faraz Tavili, Hussein A. Ghanimi, Hussein A. Ghanimi, Arash Abdolmaleki, Maedeh Naghizadeh Published: Thursday, September 10, 2026

Commentary The cricket brain: a tractable system for decoding neural aging Gerald Yu Liao, Ariana Rhim, Jackson Wezeman, Warren Ladiges Published: Thursday, September 10, 2026

Research Article Development of an organotypic brain slice culture model for testing resilience to aging using tissues collected from geriatric mice Addison Keely, Jackson Wezeman, Savanna Roberts, Sonali Bhana, Warren Ladiges Published: Thursday, September 10, 2026

Commentary Rethinking sarcopenia screening in middle age—The 2025 AWGS consensus and its implications for cognitive health Chieh Chen, Da-Ming Liao Published: Friday, August 28, 2026

Model Profile Destabilization of the medial meniscus in geriatric mice captures functional decline in age-associated osteoarthritis Gerald Yu Liao, Megan Ellis, Jessica Snyder, Warren Ladiges Published: Friday, August 28, 2026

Review Neuroinflammation across neurodegenerative diseases: an aging-conditioned convergence–divergence framework for precision neuroimmunology Mohammad Harun-Ur-Rashid, Israt Jahan Published: Thursday, August 27, 2026

Commentary Aging and memory: a personal perspective Fergus Craik Published: Thursday, August 27, 2026

Review Neuroinflammation in diabetes: from pathophysiological mechanisms to therapeutic opportunities Alma Karen Lomeli-Lepe, Dulce Elena Silva-Silverio, Mónica Elisa Ureña-Guerrero, Silvia Josefina López-Pérez Published: Tuesday, August 25, 2026

Review Neuroinflammation and humoral immunity across chronic diseases: mechanisms, biomarkers, and therapeutic implications Lidija Radenovic Published: Friday, August 21, 2026

Therapeutic Brief Voluntary wheel running enhances neuronal BDNF in very old C57BL/6 mice Gina Israel, Ruby Sue Mangalindan, Warren C Ladiges, Addison Keely Published: Tuesday, June 30, 2026

Mini Review The microgram hypothesis: a translational dosing error in Epitalon peptide research and its implications for human aging application Chang-Hun Jung Published: Tuesday, June 30, 2026

Mini Review Countering oxysterol-driven neurodegeneration: diosgenin as a privileged steroidal scaffold for novel Alzheimer’s disease therapeutics Sarvesh Sabarathinam Published: Tuesday, June 30, 2026

Letter to Editor Low-dose radiotherapy for severe osteoarthritis refractory to conservative treatment in older adults: an underexplored option Jorge Andrés Sánchez Duque, María Camila Fernández-Gualdron, Miguel M Moreno-Capacho, Holman Duvan Ballesteros-Gomez Published: Tuesday, June 30, 2026