Most Viewed Articles

Mini Review Drug nanotargeting for treatment of neurodegeneration and aging Joseph S. D'Arrigo Published: Tuesday, June 29, 2021 Viewed: 87123

Therapeutic Brief The potential of GHK as an anti-aging peptide Warren Ladiges, Yan Dou, Amanda Lee, Lida Zhu, John Morton Published: Friday, March 27, 2020 Viewed: 33833

Case Report Irreversible effects of anticholinergic withdrawal in the elderly: a case report Charisse Chehovich, Claudia Lee, Tammie Lee Demler Published: Tuesday, June 29, 2021 Viewed: 18550

Mini Review The potential of astaxanthin as a natural compound for decelerating skin aging: an update review Teresa Liliana Wargasetia, Ratna Sariharyanti, Hana Ratnawati Published: Thursday, December 26, 2024 Viewed: 15034

Research Article Leucine metabolite β-hydroxy-β-methyl butyrate (HMB) supplementation on muscle mass during resistance training in older subjects: meta-analysis Guangqin Zou, Quan Wang, Hua Wan, Xiang Lu, Wei Gao Published: Wednesday, March 30, 2022 Viewed: 11183

Research Article Sleep-deprived cognitive impairment in aging mice is alleviated by rapamycin Warren Ladiges, Kishore Mukherjee, Amanda Lee, Lida Zhu, Martin Darvas Published: Monday, December 30, 2019 Viewed: 10213

Conference Abstract Resilience in aging and age-related disease. Abstracts from the 2019 Barshop Conference on Aging Warren Ladiges, Yuji Ikeno, Liang Wang Published: Friday, March 27, 2020 Viewed: 9979

Case Report Novel LMNA mutations in Greek and Myanmar Patients with Progeroid Features and Cardiac Manifestations Junko Oshima, Renuka Kandhaya-Pillai, Fuki M Hisama, Stephanie A Bucks, Soe Yarzar, Haroula Korovou, George M Martin Published: Monday, June 29, 2020 Viewed: 9936

Review The rationale for testing drug combinations in aging intervention studies Kavita C Sharma, Juan Wang, Zhou Jiang, Jenna Klug, Martin Darvas, Denise M Imai, Timothy Snider, Laura Niedernhofer, Warren C Ladiges Published: Monday, December 30, 2019 Viewed: 9750

Research Article Clinical diagnosis and treatment of primary small intestinal lymphoma Guitian Huang Published: Thursday, September 30, 2021 Viewed: 9528

Research Article Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice Kaitlin Nickel, Lida Zhu, Ruby Mangalindan, Jessica M. Snyder, Jeremy Whitson, Maryia Sweetwyne, Ana P. Valencia, Jenna Klug, Zhou Jiang, David J. Marcinek, Peter Rabinovitch, Warren Ladiges, Matthew Tucker Published: Friday, September 30, 2022 Viewed: 9132

Research Article Highly expressed ribosomal protein L34 predicts poor prognosis in acute myeloid leukemia and could be a potential therapy target Liang Wang, Jing Yang, Henan Wang, Weida Wang, Xiaojie Liang Published: Friday, March 27, 2020 Viewed: 9063

Technology Feature QuPath. A new digital imaging tool for geropathology Warren Ladiges, Amanda Lee, Zhou Jiang, Lida Zhu Published: Monday, June 29, 2020 Viewed: 9016

Review Aging pet cats develop neuropathology similar to human Alzheimer’s disease Warren Ladiges, Jenna Klug, Jessica M. Snyder, Martin Darvas, Denise M. Imai, Molly Church, Caitlin Latimer, C . Dirk Keene Published: Tuesday, September 29, 2020 Viewed: 8968

Review Development of a Geropathology Grading Platform for nonhuman primates Warren Ladiges, Katie J Olstad, Denise M Imai, Rebekah I Keesler, Rachel Reader, John H Morrison, Jeffery A Roberts, John P Capitanio, Elizabeth S Didier, Marcelo J Kuroda, Heather Simmons, Shabnam Salimi, Julie A Mattison, Yuji Ikeno Published: Friday, March 27, 2020 Viewed: 8926

Research Article LINC00271 inhibits epithelial-mesenchymal transition of papillary thyroid cancer cells by downregulating trefoil factor 3 expression Jianda Dong, Pihong Li, Xiaoyu Pan, Zhouci Zheng, Yihan Sun, Yifan Han Published: Monday, June 29, 2020 Viewed: 8902

Model Profile The CB6F1 mouse is a model for studying cognition and brain morphometry with increasing age Warren Ladiges, Davika Gandhay, Christina Pettan Brewer Published: Wednesday, March 29, 2023 Viewed: 8833

Therapeutic Brief Molecular hydrogen may activate the transcription factor Nrf2 to alleviate oxidative stress through the hydrogen-targeted porphyrin Shigeo Ohta Published: Tuesday, May 23, 2023 Viewed: 8791

Research Article Thioredoxin overexpression in mitochondria showed minimum effects on aging and age-related diseases in male C57BL/6 mice Madeline G. Roman, Lisa C. Flores, Geneva M. Cunningham, Christie Cheng, Sara Dube, Colton Allen, Holly Van Remmen, Yidong Bai, Thomas L. Saunders, Yuji Ikeno Published: Friday, March 27, 2020 Viewed: 8776

Review Progress on the study of fibroblast growth factors as novel therapeutics in post-stroke cognitive impairment Hong Fan, Mengqi Li Published: Thursday, September 30, 2021 Viewed: 8501

Research Article Sex-dependent lifespan extension of ApcMin/+ FAP mice by chronic mTOR inhibition Manish Parihar, Sherry G Dodds, Marty Javors, Randy Strong, Paul Hasty, Zelton Dave Sharp Published: Thursday, December 31, 2020 Viewed: 8261

Commentary Resilience to aging is a heterogeneous characteristic defined by physical stressors Haoyi Lei, Derek M. Huffman, Adam B. Salmon, Nathan K. LeBrasseur, Christy Carter, Arlan Richardson, Steve Austad, Warren Ladiges Published: Wednesday, March 30, 2022 Viewed: 8258

Geropathology Notes Eosinophilic crystalline pneumonia, an age-related lesion in mice Jenna J Klug, Jessica M Snyder Published: Thursday, December 31, 2020 Viewed: 8218

Case Report Drug-Induced Hemolytic Crisis During Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma: A Rare Hematologic Adverse Reaction Xin Wen, Liang Wang, Yingzhi He, Shan Wang Published: Monday, December 30, 2019 Viewed: 8162

Research Article Interfering with miR-24 alleviates rotenone-induced dopaminergic neuron injury via enhancing autophagy by upregulating DJ-1 Fengrui Li, Biao Ge, Hairong Wu, Dan Shao, Shulin Li Published: Monday, December 30, 2019 Viewed: 8155

Review Thioredoxin and aging: What have we learned from the survival studies? Lisa C. Flores, Madeline G. Roman, Geneva M. Cunningham, Christie Cheng, Colton Allen, Gene Borden Hubbard, Yidong Bai, Thomas L. Saunders, Yuji Ikeno Published: Tuesday, September 29, 2020 Viewed: 8092

Model Profile A model for studying cutaneous wound healing and resilience to aging: Ear punch biopsy in old mice Warren Ladiges, Zhou Jiang, Jessie Chen, Juan Wang, Ruby Mangalindan, Lida Zhu Published: Tuesday, September 29, 2020 Viewed: 8037

Research Article Down-regulation of miR-181a promotes microglial M1 polarization through increasing expression of NDRG2 Bo Zhou, Yali Niu, Chunxiao Wan, Rui wu, Heying Sun, Danqing Lu Published: Friday, March 27, 2020 Viewed: 7984

Editorial Progress in drug treatment of elderly chronic heart failure Feng Liu, Siting Zhang Published: Thursday, December 31, 2020 Viewed: 7969

Research Article Mitochondrial-targeted methionine sulfoxide reductase overexpression increases the production of oxidative stress in mitochondria from skeletal muscle Adam B. Salmon, Arunabh Bhattacharya, Daniel Pulliam, Yuhong Liu Published: Friday, March 27, 2020 Viewed: 7806

Research Article MicroRNA-152 suppresses cell proliferation and tumor growth of bladder cancer by targeting KLF5 and MKK7 Liangliang Wang, Yu Hui, Yuhua Huang, Xiang Ding Published: Monday, December 30, 2019 Viewed: 7786

Review Gastrointestinal Disasters of Cetuximab in the Treatment of Metastatic Colorectal Cancer: Mechanism and its Effect on Prognosis Junfeng Sun, Yue Wu, Haowei Jia, Xinqi Bao, Tianyu Zhu, Ruixin Li, Hongchao Zhao Published: Monday, June 29, 2020 Viewed: 7777

Review The cellular senescence unification model and telomerase therapy: To treat all age-related diseases Steve Liebich Published: Tuesday, September 29, 2020 Viewed: 7736

Model Profile A mouse model of sleep deprived neuropathology to study resilience to Alzheimer’s disease Warren Ladiges, Yan Dou, Jinzi Wu, Lida Zhu, Martin Darvas Published: Monday, June 29, 2020 Viewed: 7570

Case Report Coronary artery stenosis regression by long-term standard dose statin therapy in middle-aged and elderly patients: Report and analysis of 31 cases Feng Liu, Zhilei Ren, Chongzhe Yang, Kaihua Huang Published: Tuesday, September 29, 2020 Viewed: 7562

Editorial Time for an Alzheimer’s disease cocktail Warren Carl Ladiges Published: Friday, March 27, 2020 Viewed: 7541

Research Article Pioglitazone up-regulates MALAT1 and promotes the proliferation of endothelial progenitor cells through increasing c-Myc expression in type 2 diabetes mellitus Xiaoxu Yang, Chen Hu, Yan Sun Published: Friday, March 27, 2020 Viewed: 7424

Research Article Resilience to acute sleep deprivation is associated with attenuation of hippocampal mediated learning impairment Warren Ladiges, Amanda Lee, Haoyi Lei, Lida Zhu, Zhou Jiang Published: Thursday, December 31, 2020 Viewed: 7411

Research Article IL-17 regulates the expression of major histocompatibility complex II and VEGF in DLBCL mice on tumor growth Xin Xu, Ting Wei, Weijie Zhong, Zhigang Zhu, Feng Liu, Qingshan Li Published: Monday, June 29, 2020 Viewed: 7373

Review Sarcopenia and falls in older adults Chieh Chen, Daming Liao Published: Friday, September 30, 2022 Viewed: 7267

Research Article Di-2-pyridylketone 4, 4-dimethyl-3-thiosemicarbazone effectively induces human colorectal carcinoma cell apoptosis via mTOR pathway Qianqian Fu, Shengli Wang, Chuyun Zhu, Zhenlong Zhou, Xiaojuan Yu, Yong Zhang Published: Thursday, September 30, 2021 Viewed: 7206

Research Article Effect of Pilates versus resistance training on physical fitness in older adults Manisha Ashish Rathi, Khushboo Muthiyan, Reema Joshi, Preeti Gazbare Published: Thursday, September 12, 2024 Viewed: 7202

Review Guidelines for the Prevention of Coronavirus Pneumonia in Elderly People Wei Ma, Jun Zhao, Gang Xu, Congrui Feng, Yuluo Chen, Feng Liu Published: Monday, June 29, 2020 Viewed: 7150

Review Age effect on mesenchymal stem cell properties: A concise review Tsz Kin Ng, Chong-Bo Chen, Xin Bin, Yuqiang Huang, Herman S. Cheung Published: Tuesday, May 23, 2023 Viewed: 7095

Editorial Microbiome in aging of Gut and Brain (MiaGB): paving the ways to understand gut-brain axis in aging Michal M. Masternak, Hariom Yadav Published: Wednesday, March 30, 2022 Viewed: 7089

Therapeutic Brief Physical performance is enhanced in old mice fed a short term diet medicated with rapamycin, acarbose, and phenylbutyrate Warren Ladiges, Megan Ellis, Zhou Jiang Published: Monday, March 29, 2021 Viewed: 7026

Letter to Editor Negative health effects of low testosterone concentrations in older adults Chieh Chen, Da-Ming Liao Published: Thursday, February 29, 2024 Viewed: 6972

Research Article Finding prodromal frailty in a community-dwelling healthy older cohort by survey of BDNF or hand grip strength classified by BMI Mitsugu Hachisu, Masahiro Hashizume, Hisashi Kawai, Motonaga Kojima, Yoshinori Fujiwara, Shuichi Obuchi, Mari Kogo, Masayuki Ohbayashi, Noriko Koyama, Miki Takenaka, Kazushige Ihara Published: Tuesday, September 29, 2020 Viewed: 6943

Technology Feature An immune stress test for resilience to aging: Pneumococcal vaccine response Warren Ladiges, Ryan Oveson, Zhou Jiang, Michali Izhak, Kavita Sharma Published: Tuesday, September 29, 2020 Viewed: 6935

Research Article Association of anemia with rehabilitation outcome for subacute geriatric rehabilitation patients in a secondary hospital in malaysia Mann Leon Chin, Christopher WS Chan, Huey Ee Chong, Wee Kooi Cheah Published: Friday, December 31, 2021 Viewed: 6913

Therapeutic Brief Gam-COVID-Vac (Sputnik V): a heterologous adenoviral vector-based COVID-19 vaccine Shyh Poh Teo, Sanny Zi Lung Choo Published: Tuesday, June 29, 2021 Viewed: 6867

Therapeutic Brief The potential of XPO1 inhibitors as a game changer in relapsed/refractory hematologic malignancies Henan Wang, Liang Wang, Jing Yang Published: Monday, June 29, 2020 Viewed: 6840

Review The critical role of macrophages in ovarian cancer treatment Yiran Wang, Mingyi Wang Published: Friday, September 30, 2022 Viewed: 6821

Research Article KDClassifier: A urinary proteomic spectra analysis tool based on machine learning for the classification of kidney diseases Wanjun Zhao, Yong Zhang, Xinming Li, Yonghong Mao, Changwei Wu, Lijun Zhao, Fang Liu, Jingqiang Zhu, Jingqiu Cheng, Hao Yang, Guisen Li Published: Thursday, September 30, 2021 Viewed: 6786

Commentary Geropathology. An inside view of biological aging Warren Ladiges Published: Wednesday, March 30, 2022 Viewed: 6751

Research Article Anti-tumor effect of pcDNA3.1(-)/rMETase-shUCA1 hyaluronic acid-modified G5 polyamidoamine nanoparticles on gastric cancer Chunying Xie, Zhenxing Huang, Zhaohui Huang, Yanyan Guo, Xue Zhang Published: Monday, June 29, 2020 Viewed: 6743

Therapeutic Brief Short-term oral rapamycin prevents age-related learning impairment in mice Warren Ladiges, Haoyi Lei, Juan Wang, Zhou Jiang Published: Tuesday, September 29, 2020 Viewed: 6735

Research Article Thioredoxin down-regulation in the cytosol in thioredoxin 2 transgenic mice did not have beneficial effects to extend lifespan in male C57BL/6 mice Lisa C. Flores, Madeline G. Roman, Geneva M. Cunningham, Christie Cheng, Colton Allen, Yidong Bai, Gene B. Hubbard, Yuji Ikeno Published: Thursday, December 31, 2020 Viewed: 6720

Review Evidence for an alternative insulin transporter at the blood-brain barrier Elizabeth M Rhea, William A Banks, Cassidy Noonan Published: Tuesday, May 23, 2023 Viewed: 6720

Editorial Oxidative stress in aging: stayin’ alive? Lisa C. Flores, Yuji Ikeno Published: Monday, June 29, 2020 Viewed: 6698

Review Recent advances in the genetic association between osteoporotic fracture and sarcopenia Qiaocong Chen, Huiling Lou, Cheng Peng Published: Monday, March 29, 2021 Viewed: 6646

Case Report Nasal type extranodal natural killer/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis: a Case report and literature review Xuelin Liu, Liqiang Wei, Jing Yang, Jin Ye, Liang Wang Published: Wednesday, March 30, 2022 Viewed: 6628

Case Report Spontaneous chordoma: a case report on a female UM-HET3 mouse from the SLAM study Eleonora Duregon, Rafael de Cabo, Camila Vieira Ligo Teixeira, Dushani L. Palliyaguru, Annamaria L. Rudderow, Victoria Hoffmann, Michel Bernier, Nathan L. Price, Simonetta Camandola Published: Thursday, December 31, 2020 Viewed: 6618

Review Senescence of mesenchymal stem cells: implications in extracellular vesicles, miRNAs and their functional and therapeutic potentials Guangqian Zhou, Liangge He, Mingzhu Li, Zhen Liu, Arshad Ahmed Padhiar Published: Tuesday, October 17, 2023 Viewed: 6591

Review Myocardial Cell Aging in the Elderly Feng Liu, Wenxi Li Published: Tuesday, September 29, 2020 Viewed: 6560

Research Article miR-181c inhibits prostatic epithelial cell proliferation caused by chronic non-bacterial prostatitis through down-regulating COX-2 Xiang Ding, Xu Xu, Yuhua Huang, Jianquan Hou, Jinxing Lv Published: Thursday, December 31, 2020 Viewed: 6548

Model Profile Neutrophil response to cyclophosphamide predicts resilience to age-related learning impairment Lida Zhu, Warren Ladiges, Katie Nickel, Marianne Bjorner Published: Thursday, December 31, 2020 Viewed: 6429

Commentary The unrecognized potential of pet cats for studying aging and age-related diseases Warren Ladiges Published: Friday, December 31, 2021 Viewed: 6403

Commentary A geropathology approach for identifying therapeutic targets to prevent pathological complications of COVID-19 Warren Ladiges, Yuji Ikeno, Liang Wang, Feng Liu Published: Monday, June 29, 2020 Viewed: 6376

Review Application and research progress of BCL2 inhibitors in elderly patients with hematologic malignancies Liang Wang, Yufan Wang Published: Thursday, December 31, 2020 Viewed: 6350

Review Safety and efficacy of the Novavax vaccine—a narrative review Shyh Poh Teo, Sanny Zi Lung Choo Published: Friday, December 31, 2021 Viewed: 6349

Geropathology Notes Hepatic steatosis, a lesion reported in captive aged common marmosets Sebastian Eduardo Carrasco, Olga Lucia Franco-Mahecha Published: Monday, March 29, 2021 Viewed: 6341

Research Article PathoClock and PhysioClock in mice recapitulate human multimorbidity and heterogeneous aging Warren Ladiges, Shabnam Salimi, Christina Pettan-Brewer Published: Friday, December 31, 2021 Viewed: 6280

Therapeutic Brief The antidiabetic drug acarbose suppresses age-related lesions in C57BL/6 mice in an organ dependent manner Zhou Jiang, Sneh Gupta, Warren Ladiges Published: Tuesday, June 29, 2021 Viewed: 6244

Review Advances in targeting programmed cell death 1/programmed cell death-ligand 1 therapy for hematological malignancies Liang Wang, Yuanzheng Liang, Wanying Zhao Published: Friday, December 31, 2021 Viewed: 6098

Therapeutic Brief Denosumab for the treatment of osteoporosis Shyh Poh Teo Published: Tuesday, September 29, 2020 Viewed: 6071

Therapeutic Brief GHK peptide prevents sleep deprived learning impairment in aging mice Warren Ladiges, Manuela Rosenfeld, Katie Nickel Published: Wednesday, March 29, 2023 Viewed: 6058

Case Report A fornix infarction causing post-operative anterograde amnesia Shyh Poh Teo Published: Tuesday, June 29, 2021 Viewed: 6036

Research Article Technical development of senescence-associated β-galactosidase staining in frozen kidney tissue of Sprague Dawley rat Yuji Ikeno, Ganga Tandukar, Lisa C. Flores, Colton Allen, Yidong Bai Published: Tuesday, September 24, 2024 Viewed: 6033

Editorial Chimeric antigen receptor T cell therapy in cancer: Advances and challenges Yuanzheng Liang, Liang Wang Published: Thursday, September 30, 2021 Viewed: 6023

Letter to Editor Optimal induction treatment regimens for extranodal NK/T-cell lymphoma: lessons learned, challenges, and proposals Liang Wang, Jing Yang, Ruiying Fu, Xindi Liu, Liqiang Wei Published: Thursday, December 31, 2020 Viewed: 5946

Case Report Castleman disease with rapidly progressive pemphigus: case report Liang Wang, Ruiying Fu, Yingzhi He Published: Thursday, December 31, 2020 Viewed: 5915

Letter to Editor Preventive effect of rehabilitation training therapy on muscle quality in patients with stroke: A retrospective study Xiang Lu, Dandan Feng, Wei Gao, Can Zhao, Dan Chen, Xiaojing He Published: Friday, December 31, 2021 Viewed: 5909

Review Vitiligo as a potential degenerative disease: from oxidative stress to cellular senescence Yaojun Wang, Jiaoni Chi, Tao Wang, Yue Zhang, Zhimin Li, Jie Chen, Haixia Liu, Qiang Li Published: Thursday, June 30, 2022 Viewed: 5804

Conference Abstract The aging immune system. Abstracts presented at the Masoro-Barshop conference on aging, October 13-15, 2021 Warren Ladiges Published: Friday, December 31, 2021 Viewed: 5782

Editorial Immunotherapy: the blockbuster in cancer treatment Liang Wang Published: Tuesday, September 29, 2020 Viewed: 5753

Model Profile A mouse model of naturally occurring age-related cognitive impairment Sara Daneshjoo, Jualiana Moreno, Manuela Rosenfeld, Joo Young Park, Martin Darvas, Warren Ladiges Published: Friday, September 30, 2022 Viewed: 5741

Letter to Editor Arthritis as an adverse event of special interest post COVID-19 vaccine implementation Shyh Poh Teo Published: Monday, March 29, 2021 Viewed: 5713

Commentary Precision aging. Human lifespan has intrinsic limits but measurable outcomes Warren Ladiges Published: Tuesday, June 29, 2021 Viewed: 5649

Review Role of microRNAs in skin aging and its potential therapeutic interventions Deusdedit Tusubira, Ashikha Shirin Usman PP, Durairaj Sekar Published: Tuesday, June 25, 2024 Viewed: 5625

Editorial Thioredoxin – a magic bullet or a double-edged sword for mammalian aging? Yuji Ikeno Published: Tuesday, June 29, 2021 Viewed: 5618

Editorial Harnessing the heterogeneity of aging Warren Ladiges Published: Monday, March 29, 2021 Viewed: 5594

Case Report Cardiac arrest in an older male patient treated with flecainide for atrial fibrillation Tiziana Ciarambino, Rosario Bottone, Gennaro Sansone, Mauro Giordano Published: Tuesday, June 29, 2021 Viewed: 5576

Commentary Pharmaceutical interventions to slow human aging. Are we ready for cocktails? Warren Ladiges, Manuela Rosenfeld Published: Thursday, June 30, 2022 Viewed: 5576

Review Mechanisms of autophagy regulation by adiponectin Xin Xu, Chan Rong Published: Friday, December 31, 2021 Viewed: 5547

Commentary Mouse modeling for anxiety disorders in older adults Martin Darvas, Warren Ladiges, Nadia Postupna Published: Thursday, September 30, 2021 Viewed: 5545

Mini Review Role of fibro-adipogenic progenitors in skeletal muscle aging Renwen Wan, Hanli Zhang, Shan Liu, Chunmeng Jiao, Hui Chen, Zhiwen Luo, Xiliang Shang Published: Wednesday, June 28, 2023 Viewed: 5494

Commentary Targeting IGF1R signaling for brain aging and Alzheimer’s disease Warren Ladiges, Joo Young Park, Martin Darvas Published: Thursday, December 29, 2022 Viewed: 5374

Reviewer Acknowledgement 2020 Reviewer Acknowledgment Editorial Office of Aging Pathobiology and Therapeutics Published: Thursday, December 31, 2020 Viewed: 5353

Case Report Older female relatives of Covid-19 patients have an un-satisfactory perception of emergency room performance by clinical staff Tiziana Ciarambino, Luigia Palmiero, Rosario Bottone, Federico Schettini, Luigi Elio Adinolfi, Mauro Giordano Published: Tuesday, June 29, 2021 Viewed: 5342

Review A review of variable risk factors affecting the development of mild cognitive impairment in older adults Chenghui Zhang, Hong Fan, Mengqi Li Published: Tuesday, December 26, 2023 Viewed: 5281

Commentary The naturally occurring peptide GHK reverses age-related fibrosis by modulating myofibroblast function Warren Ladiges, Qianpei He, Jordan Mazzola Published: Thursday, December 26, 2024 Viewed: 5268

Mini Review Human microbiota alterations — emerging predictors of renal diseases and kidney-specific aging Chao Zhao, Miaomiao Pan, Ming Zhang, Xingyu Rong Published: Wednesday, March 29, 2023 Viewed: 5204

Commentary The house cricket is an unrecognized but potentially powerful model for aging intervention studies Warren Ladiges, Gerald Yu Liao, Manuela Rosenfeld, Jackson Wezeman Published: Tuesday, March 19, 2024 Viewed: 5201

Research Article Targeted regulation of senescence-associated secretory phenotype with an aptamer-conjugated activatable senomorphic Yanlan Liu, Yuqi Xie, Jili Li, Pingyu Wu, Linlin Wang, Donghui Hong, Jian Wang Published: Wednesday, June 28, 2023 Viewed: 5075

Research Article Behavioral and neuropathological features of Alzheimer’s disease are attenuated in 5xFAD mice treated with intranasal GHK peptide Matthew Tucker, Gerald Yu Liao, Joo Young Park, Manuela Rosenfeld, Jackson Wezeman, Ruby Mangalindan, Dan Ratner, Martin Darvas, Warren Ladiges, Addison Keely Published: Monday, August 26, 2024 Viewed: 4996

Review Research progress in the PD-1/PD-L1 pathway and IL-17A in lymphomas Li Yang, Xin Xu Published: Thursday, June 30, 2022 Viewed: 4946

Interview On the growth of young neurologists—an interview with Prof. Louis R. Caplan Qi Qin Published: Friday, September 30, 2022 Viewed: 4924

Commentary Sex matters in aging. The canagliflozin story Warren Ladiges, Jackson Wezeman Published: Friday, September 30, 2022 Viewed: 4902

Editorial Targeting metabolism through exercise and nutrition to rejuvenate an aging immune system Brandt D. Pence Published: Friday, September 30, 2022 Viewed: 4680

Research Article Molecular docking and ADMET analysis of coenzyme Q10 as a potential therapeutic agent for Alzheimer's disease Abdullah Al Noman, Pranab Dev Sharma, Tasmia Jahin Mim, Md Al Azad, Himanshu Sharma Published: Thursday, December 26, 2024 Viewed: 4678

Commentary Withania somnifera: a promising neuroprotective ally against Alzheimer's disease Rajaram Mohapatra, Pratikeswar Panda Published: Thursday, December 26, 2024 Viewed: 4676

Mini Review The microgram hypothesis: a translational dosing error in Epitalon peptide research and its implications for human aging application Chang-Hun Jung Published: Tuesday, June 30, 2026 Viewed: 4570

Review Proteostasis in aging: mechanistic insights and therapeutic opportunities Gaurav N. Kasar, Pooja B. Rasal, Chandrashekhar D. Patil, Sunil K. Mahajan, Aman B. Upaganlawar Published: Thursday, March 6, 2025 Viewed: 4569

Research Article A reappraisal of the measured concentration of voriconazole based on plasma albumin concentration during its therapeutic drug monitoring Fangmin Xu, Yexuan Wang, Xiaoshan Zhang, Junhui Yu, Liwen Zhang, Xuben Yu, Haina Zhang Published: Thursday, June 30, 2022 Viewed: 4566

Mini Review Sotrovimab for treatment of COVID-19 infections Shyh Poh Teo Published: Thursday, June 30, 2022 Viewed: 4515

Review Influence of metformin on age-related macular degeneration Albert J Augustin, Jenny Atorf Published: Tuesday, May 23, 2023 Viewed: 4433

Editorial Get back–calorie restriction: Dr. Masoro’s legacy Yuji Ikeno, Lisa C. Flores Published: Thursday, June 30, 2022 Viewed: 4416

Commentary The Eph receptor A4-mediated demyelination in depression Quanguang Zhang, Luodan Yang Published: Thursday, December 29, 2022 Viewed: 4408

Review Cardiovascular aging in patients with chronic kidney disease: pathogenesis and potential therapeutics Safa Alkhayyat, Mohamed Abdalbary, Zahraa Alhoori Published: Thursday, September 28, 2023 Viewed: 4407

Review Fasting helps nutrient sensing systems in clocking the metabolism Neelu Jain Gupta Published: Tuesday, June 25, 2024 Viewed: 4322

Research Article Carvacrol induces osteogenic differentiation of BMSCs and alleviates osteolysis in aged mice by upregulating lncRNA NEAT1 to promote SIRT1 expression Zefeng Xu, Zeyu Wang, Wenming Ma, Zhihui Huang Published: Tuesday, December 26, 2023 Viewed: 4273

Research Article Additional polgD257A mutation (mutator) does not influence dopaminergic neurodegeneration in aged parkin-deficient mice Xin-Ran Zhu, David Mrohs, Max Rybarski, Michael Andriske, Pauline Bohne, Melanie D. Mark, Hermann Lübbert Published: Tuesday, May 23, 2023 Viewed: 4222

Review The role of immune aging in giant cell arteritis Patricia Harkins, Sharon Cowley, Robert Harrington, David Kane, Richard Conway Published: Thursday, September 28, 2023 Viewed: 4165

Therapeutic Brief Difference in the effectiveness of subthalamic nucleus and globus pallidus deep brain stimulation in Parkinson’s disease Hushyar Azari Published: Thursday, June 30, 2022 Viewed: 4122

Review Exploring the interplay of leptin and aging: insights into the role of gut microbiota Harish Rangareddy, Rajhi Hayfa, Venkateshappa Chikkanarayanappa, Ashakiran Srinivasaiah, Reshma Devarajachar Published: Friday, April 12, 2024 Viewed: 4069

Interview On the original aspiration of researching neurodegenerative diseases—an interview with Prof. Jeffrey Kordower Min Zhu Published: Thursday, December 29, 2022 Viewed: 4064

Interview On the frontier of immunogerontology—an interview with Prof. Graham Pawelec Xiaodong Li Published: Friday, September 30, 2022 Viewed: 4043

Review Nrf2 participates in progression of osteoarthritis through modulating redox balance Yueqi Chen, Zihan Deng, Chuan Yang Published: Thursday, September 28, 2023 Viewed: 4031

Reviewer Acknowledgement 2021 Reviewer Acknowledgment Editorial Office of Aging Pathobiology and Therapeutics Published: Friday, December 31, 2021 Viewed: 4001

Interview On the frontier of chronic obstructive pulmonary disease—an interview with Prof. Peter J Barnes Wei Ma Published: Thursday, December 29, 2022 Viewed: 3963

Editorial Biological age from a pathological perspective Warren Ladiges Published: Wednesday, March 29, 2023 Viewed: 3948

Commentary In vitro geroscience. Screening anti-aging drug combinations for neurodegenerative diseases Warren Ladiges, Soroosh Fatemi, Joo Young Park Published: Wednesday, June 28, 2023 Viewed: 3882

Research Article Older-aged C57BL/6 mice fed a diet high in saturated fat and sucrose for ten months show decreased resilience to aging Chloe N Johnson, Lida Zhu, Ruby Mangalindan, Jeremy Whitson, Maryia Sweetwyne, Ana P. Valencia, David J. Marcinek, Peter Rabinovitch, Warren Ladiges Published: Thursday, September 28, 2023 Viewed: 3857

Research Article Statins adherence and associated muscle symptoms in elderly coronary heart disease patients Marat V Ezhov, Marina G. Bubnovaa, David M. Aronov Published: Tuesday, December 26, 2023 Viewed: 3851

Review Inflammaging and microbiota: the intersection of aging, inflammation, and gut health Harish Rangareddy, Jessica Fryer, Achal Shetty, Hayfa Rajhi Published: Friday, June 27, 2025 Viewed: 3811

Research Article Voluntary wheel running is a non-invasive test to measure physical performance in aging mice Christina Pettan-Brewer, Addison Keely, Warren Ladiges Published: Tuesday, December 26, 2023 Viewed: 3801

Research Article Effects of mitochondrial fusion and fission regulation on mouse hippocampal primary cultures: relevance to Alzheimer's disease Alina Vadimovna Chaplygina, Daria Yurievna Zhdanova Published: Friday, April 12, 2024 Viewed: 3742

Case Report The case of a geriatric female experiencing frequent falls and epileptic seizures during long-term low-dose clozapine and extended-release bupropion treatment Charisse Dzierba, Claudia Lee, Tammie Lee Demler Published: Wednesday, June 28, 2023 Viewed: 3739

Editorial Is aging “normal”? Warren Ladiges, Chloe Johnson Published: Thursday, December 29, 2022 Viewed: 3662

Research Article Serum elementomic analysis indicates a panel of elements related with age Hui-Xian Sun, Kai-Yue Jia, Yan-Ru Li, Can Zhao, Xiang Lu, Wei Gao Published: Friday, February 23, 2024 Viewed: 3642

Mini Review Research advances in stem cell transplantation combined with fibrin scaffold for treating spinal cord injury in an aging society Yongxiong He, Tianqi Jiang, Zhijun Chen, Yitong Luo, Xinyue Tian, Hua Yang Published: Thursday, March 7, 2024 Viewed: 3621

Review Gut microbiome and neurodegenerative disorders: therapeutic Implications Sugato Banerjee, Ritika Ruwatia, Suparna Roy Sarkar, Subhamoy Panda Published: Thursday, November 21, 2024 Viewed: 3619

Editorial Ethylnitrosourea-induced gliomas: a song in the attic? Yuji Ikeno Published: Wednesday, June 28, 2023 Viewed: 3616

Research Article Exploring the complex interplay between anxiety, aging, and behavior in CB6F1 and C57BL/6 mice: implications for cognitive function Gerald Yu Liao, Kunyuan Li, Addison Keely, Shuliang Yu, Christina Pettan-Brewer, Warren Ladiges Published: Monday, March 25, 2024 Viewed: 3550

Review Diverse models in Alzheimer's research: exploring alternative approaches beyond traditional rodent frameworks Govind Singh, Payal Chauhan, Karan Wadhwa Published: Thursday, December 26, 2024 Viewed: 3446

Interview On the treatment of Parkinson’s disease—an interview with Prof. Nir Giladi Siyan Chen Published: Tuesday, December 26, 2023 Viewed: 3381

Research Article Cigarette exposure and aging pathways: interplay between IGF-1 suppression and TGF-β increase Titiek Hidayati, Akrom Akrom, Suny Sun Published: Sunday, September 28, 2025 Viewed: 3338

Mini Review Biobased nanoemulsions for targeted drug delivery to treat dementia and aging Joseph S. D'Arrigo Published: Thursday, September 28, 2023 Viewed: 3250

Model Profile Cartilage organoid model of osteoarthritis to study aging-related diseases Guangxuan Yan, Yongxiong He, Zhiqiang Shi, Yuan Li, Kai Tao, Jun Fan, Qiankun Zhu, Heng Wang, Aitao Wang, Yongchao Li Published: Friday, June 27, 2025 Viewed: 3244

Interview On epigenetic clocks and cancer risk—an interview with Prof. Andrew E. Teschendorf Shikha Sharma Published: Tuesday, December 26, 2023 Viewed: 3205

Editorial Physical resilience is a predictor of healthy aging Warren Ladiges Published: Thursday, September 28, 2023 Viewed: 3139

Mini Review Modeling resilience to sleep disruption to study resistance to Alzheimer’s disease Warren Ladiges, Jordan Mazzola, Joo Young Park Published: Tuesday, December 26, 2023 Viewed: 3128

Review A mechanistic narrative review of phytochemical enhancement of mitophagy in Parkinson’s disease: from PINK1/Parkin pathways to dopaminergic neuroprotection Peace Ayo Olaoluwa, Abraham Olufemi Asuku, Patrick Oluwole Abolarin, Ayodeji Johnson Ajibare, Gideon Opeyemi Ayilara Published: Tuesday, March 31, 2026 Viewed: 3068

Review Epigenetic mechanisms of the influence of aging on the development of breast cancer with the participation of retroelements Rustam Nailevich Mustafin Published: Friday, August 15, 2025 Viewed: 3052

Editorial Importance of coordination of regional stroke centers for acute ischemic stroke Xin Xu, Yingjun Ouyang, Chan Rong Published: Tuesday, December 26, 2023 Viewed: 3009

Research Article Impact of oral vitamin D3 supplementation on proximal femur fracture incidence in the elderly population Hao Liu, Qingjun Qiu, Xuwen Luo, Bin Yuan Published: Thursday, June 20, 2024 Viewed: 2999

Commentary Resilience to aging drives personalized intervention strategies for Alzheimer’s disease Warren Ladiges, Jackson Wezeman, Addison Keely Published: Tuesday, December 26, 2023 Viewed: 2913

Interview On the growth of young geriatricians——an interview with Prof. Louis R. Caplan Chan Rong Published: Friday, December 1, 2023 Viewed: 2902

Review Beyond hallmarks of aging – biological age and emergence of aging networks S. Michal Jazwinski, Sangkyu Kim, Jessica Fuselier Published: Monday, March 31, 2025 Viewed: 2893

Research Article Effect of dual task training versus analogy training on gait speed and balance in older adults—randomized controlled trial Yashi Shah, Reema Joshi, Chetana Tetgure Published: Saturday, December 14, 2024 Viewed: 2872

Research Article Experimental confirmation of osteoarthritis repair in vivo using epigenetic reprogramming with small molecules Javdat N. Muratkhodjaev, Saodat A. Muratkhodjaeva, Tamara U. Aripova Published: Monday, September 8, 2025 Viewed: 2852

Research Article Integrative bioinformatics and molecular docking unveil multi-target therapeutic mechanisms of Coptidis Rhizoma (CR) against Lewy body dementia (LBD): an in-silico approach Pranab Dev Sharma, Abdullah Al Noman Published: Friday, June 6, 2025 Viewed: 2799

Review Heart rate recovery under healthy aging or age-related pathologies Anton R. Kiselev Published: Tuesday, December 30, 2025 Viewed: 2793

Review Resilience in the depths: anemones as models for aging and regeneration research Pooja B. Rasal, Gaurav N. Kasar, Durgesh S. Pagar, Aman B. Upaganlawar, Sunil K. Mahajan Published: Friday, July 18, 2025 Viewed: 2773

Research Article From plants to potential therapeutics: exploring neuroprotective properties against Alzheimer’s disease through molecular docking and MD simulations Ashwani Kumar, Shubham Kumar, Aanchal Gupta, Chirag N. Patel, Vikas Kumar Published: Friday, June 27, 2025 Viewed: 2716

Research Article Pharmacologic activation of delta133p53α reduces cellular senescence in progeria patients-derived cells Sebastien M. Joruiz, Patricia K. Dranchak, Natalia Von Muhlinen, Curtis C. Harris, Izumi Horikawa, James Inglese, Delphine Lissa Published: Tuesday, September 16, 2025 Viewed: 2715

Letter to Editor The role of epigenetics in cognitive aging: mechanisms, interventions, and future directions Abdullah Al Noman, Pranab Dev Sharma, Himanshu Sharma Published: Friday, June 27, 2025 Viewed: 2679

Reviewer Acknowledgement 2022 Reviewer Acknowledgment Editorial Office of Aging Pathobiology and Therapeutics Published: Thursday, December 29, 2022 Viewed: 2632

Research Article Myrmecodia platytyrea tuber aqueous extract exacerbates neuroinflammation Mizaton Hazizul Hasan, Aisyah Hasyila Jahidin, Hanish Singh Jayasingh Chellammal, Ayuni Nordin, Suraya Suratman, Mohd Faiz Mustaffa Published: Monday, February 10, 2025 Viewed: 2571

Letter to Editor Periodontal disease, cardiovascular diseases and aging-the multidirectional link Madhurya N Kedlaya, Reshma Suresh, Maya Rajan Peter, Lakshmi Puzhankara Published: Tuesday, June 25, 2024 Viewed: 2559

Interview Improving human reproductive health and fertility——an interview with Prof. Marco G. Alves Zijian Tian Published: Thursday, May 30, 2024 Viewed: 2539

Editorial Stricter definitions of myeloid senescence are needed Brandt D. Pence Published: Tuesday, June 18, 2024 Viewed: 2506

Interview Focus on cytomegalovirus and cardiovascular diseases——an interview with Prof. Patricia Price Ying Li, Jianwen Chen, Yujing Fang Published: Tuesday, June 11, 2024 Viewed: 2498

Reviewer Acknowledgement 2023 Reviewer Acknowledgment Editor Office of Aging Pathobiology and Therapeutics Published: Tuesday, December 26, 2023 Viewed: 2488

Research Article Exploring the neuroprotective potential of an iota-carrageenan in in vitro Parkinson's disease model: evaluation of pharmacological safety, antioxidant properties, and mitochondrial function Ricardo Basto Souza, Joana Silva, Celso Alves, Agnieszka Zofia Neugebauer, Vitória Virgínia Magalhães Soares, Raimundo Rafael de Almeida, Nágila Maria Pontes Silva Ricardo, Norma Maria Barros Benevides, Rui Pedrosa Published: Monday, February 10, 2025 Viewed: 2488

Letter to Editor Expanding the clinical implications of biomarkers and physiological indicators in geriatric institutionalization Jitendra Kumar Sinha, Shampa Ghosh, Krishna Kumar Singh Published: Thursday, September 11, 2025 Viewed: 2438

Research Article Effects of structured group reminiscence in sports and non-sports environments on cognitive empowerment and optimism in older adults: a quasi-experimental study Bahador Azizi, Amin Azimkhani, Mohammad Khazaei, Saleh Moazam, Nazli Ilchizadeh, Katarzyna Dzioban Published: Friday, June 27, 2025 Viewed: 2373

Review Accelerated biological ageing in type 2 diabetes mellitus: mechanistic, cellular, and systemic perspectives Simran C. Yadav, Shraddha V. Mahale, Sneha M. Nishad, Bhumika D. Bankar, Pooja B. Rasal Published: Tuesday, March 31, 2026 Viewed: 2373

Commentary Machine learning paves the way forward for geropathology assessment Gerald Yu Liao, Jenna Klug, Warren Ladiges Published: Tuesday, June 4, 2024 Viewed: 2339

Research Article Effect of continuous illumination on the ultrastructure of rat hepatocytes during ontogenesis David A. Areshidzea, Maria A Kozlova Published: Friday, September 12, 2025 Viewed: 2263

Commentary Endotoxin-induced acute lung injury in old C57BL/6J mice is a translationally relevant geroscience model Warren Ladiges, Qianpei He, Ruby S. Mangalindan, Jenna Klug Published: Tuesday, March 18, 2025 Viewed: 2252

Conference Abstract Targeting metabolic function to improve aging and healthspan: 2024 Masoro-barshop conference on aging Adam Salmon Published: Thursday, December 26, 2024 Viewed: 2204

Research Article Two-sample mendelian randomization study: vitamin D levels and chronic kidney disease in the elderly population Ling Xiao, Kaiping Luo, Honghong Zou Published: Sunday, September 29, 2024 Viewed: 2171

Interview Autophagy in neurodegeneration: recent advances, autophagosome formation, and therapeutic innovations—an interview with Prof. David Rubinsztein Aracely Garcia-Garcia Published: Thursday, December 26, 2024 Viewed: 2116

Editorial An aged rodent tissue bank fills unmet needs for biomedical research on aging Warren Ladiges Published: Tuesday, December 30, 2025 Viewed: 2102

Editorial The promise of adult neurogenesis for treating and preventing chronic neurodegenerative diseases Warren Ladiges, Gerald Yu Liao Published: Friday, September 13, 2024 Viewed: 2099

Interview Towards clinical translation of biomarkers and therapies targeting autolysosomal acidification dysfunction in neuroinflammation and neurodegeneration—an interview with Prof. David Rubinsztein Chih Hung Lo Published: Sunday, September 29, 2024 Viewed: 2075

Letter to Editor Sarcopenia and intrinsic capacity in aging: implications for geriatric physiotherapy assessment and care Weslley Barbosa Sales, Melissa Silva Rocha Pereira Published: Friday, August 29, 2025 Viewed: 2051

Interview A natural way for a healthier lifestyle—an interview with Prof. Stephen C. Bondy Alessandro Bitto Published: Friday, August 16, 2024 Viewed: 1992

Editorial Revisiting mitochondrial dysfunction in aging biology research Brandt D. Pence, Yufeng Zhang Published: Monday, March 24, 2025 Viewed: 1987

Research Article Low- vs high-load power training on muscle quality, functional performance, and multi-omic profiles in frail older adults: protocol for the FrailPow randomized controlled trial Xabier Mateos-Marañón, Iñaki Martín-Lesende, Arkaitz Larrinaga-Undabarrena, José Ramón Sánchez-Isla, Aitor Santisteban-Leguina, Iker Muñoz-Pérez, Iker Sáez, Oihana Hernández Ortiz de Urbina, Amaia Fernandez Alonso, Ana María López Rodríguez, Celia Aragón Ferrao, Irene Gómez Soto, Xabier Río Published: Tuesday, March 31, 2026 Viewed: 1955

Letter to Editor Metabolic dysfunction-associated steatotic liver disease of older people Chieh Chen, Da-Ming Liao Published: Friday, August 16, 2024 Viewed: 1933

Editorial A change is needed in the landscape of preclinical models to test drugs that target aging Warren Ladiges Published: Thursday, December 26, 2024 Viewed: 1884

Editorial Predicting resilience to aging with physical stressors Warren Ladiges Published: Friday, September 26, 2025 Viewed: 1861

Research Article No causal effect of olive oil consumption on Alzheimer’s disease: a two-sample Mendelian randomization with mediation and multivariable analyses Muhammad Iqhrammullah, Teuku Fais Duta, Derren DCH Rampengan, Nuril Farid Abshori, Bryan Gervais de Liyis, Fahrul Nurkolis Published: Tuesday, December 30, 2025 Viewed: 1837

Letter to Editor Non-drug therapy for sleep disorders in the elderly: a focus on neurofeedback technology Igor Shirolapov, Alexander Zakharov Published: Tuesday, March 31, 2026 Viewed: 1751

Research Article The loss of methionine sulfoxide reductases significantly suppresses tumor development and exacerbates kidney pathology in male quadruple Msr knockout mice Ganga Tandukar, Lisa C. Flores, Colton Allen, Yidong Bai, Jonathan Gelfond, Yuji Ikeno, Adam Salmon Published: Tuesday, December 30, 2025 Viewed: 1739

Review Non invasive techniques for muscle quality functional domain monitoring in older adults: a scoping review Naiara Virto, Xabier Río, Amaia Méndez-Zorrilla, Begoña García-Zapirain Published: Tuesday, March 31, 2026 Viewed: 1718

Research Article Dysregulation of Nrf2/ARE pathway and mitochondrial DNA damage in aging and Alzheimer’s-associated cognitive decline Polina I. Babenkova, Veronika V. Nesterova, Arina D. Tsvetkova, Anna A. Eremina, Artem P. Gureev, Vera A. Kryukova, Irina S. Sadovnikova Published: Tuesday, December 30, 2025 Viewed: 1699

Editorial The neuropathology of aging and Alzheimer’s disease in domestic cats Warren Ladiges, Ankita Sharma Published: Friday, June 27, 2025 Viewed: 1688

Review mTOR signaling in aging and longevity: therapeutic opportunities Gaurav N. Kasar, Pooja B. Rasal, Aman B. Upaganlawarb, Manoj S Mahajan Published: Tuesday, June 30, 2026 Viewed: 1683

Reviewer Acknowledgement 2024 Reviewer Acknowledgment Editor Office of Aging Pathobiology and Therapeutics Published: Thursday, December 26, 2024 Viewed: 1650

Commentary Successful aging through integrative nutrition: a four-pillar framework for deprescribing and resilience Mehrshad Fahim Devin, Mikhail Kogan, Frame A. Leigh, Lindsey Gordon, Zeynep Celikkol, Ruhsen Ozcaglayan Published: Tuesday, March 31, 2026 Viewed: 1631

Research Article The estimation of the clinical status of the residents in a geriatric health service facility in Japan Toyoki Maeda Published: Friday, June 27, 2025 Viewed: 1619

Research Article Hecogenin, a plant-derived small molecule, as a potential therapeutic intervention for neurodegenerative disorders: insights from a zebrafish model Shametha Francis Xavier, Sanjaai K M, Deepthi Padmanabhan, Anith Kumar Rajendran, Senthilkumar Palanisamy Published: Tuesday, December 30, 2025 Viewed: 1598

Research Article Associations between physical activity patterns and quality of life among hypertensive older adults: a logistic and principal component analysis Sarah Nadiya, Abdul Gani, Sri Andala, Meutia Zahra, Agusri Agusri, Liza Wahyuni Published: Tuesday, March 31, 2026 Viewed: 1583

Conference Abstract Dietary approaches to geroscience intervention: 2025 Masoro-Barshop Conference on aging Adam Salmon Published: Tuesday, December 30, 2025 Viewed: 1538

Commentary From biology of reproduction to biology of aging Andrzej Bartke Published: Tuesday, March 31, 2026 Viewed: 1532

Commentary L-Fucose is a promising gerotherapeutic drug Warren Ladiges, Jackson Wezeman, Addison Keely Published: Tuesday, December 30, 2025 Viewed: 1516

Case Report Untreated hip fracture as a trigger for rapid frailty progression: a case report Mayang Rizki Anggraeni, Etha Dini Widiasi, Novira Widajanti Published: Tuesday, December 30, 2025 Viewed: 1478

Commentary Biomarkers for prognostic stratification in chronic heart failure in older patients Anton R. Kiselev, Kseniya D. Dorogoykina Published: Friday, June 27, 2025 Viewed: 1465

Commentary Medicinal plants and healthy aging: an urgent call for robust clinical evidence Emad M. Abdallah, Wael E. Abdalla, Alaa M.M. Sadeek Published: Tuesday, December 30, 2025 Viewed: 1434

Research Article Targeting amyloid aggregation with ethanol extracts of fermented Swietenia macrophylla: a metabolomic and molecular docking approach Agustina Lulustyaningati Nurul Aminin, Bayu Fajriansyah Al-Khairi, Mukhammad Asy’ari, Muhammad Ajmal Shah Published: Tuesday, December 30, 2025 Viewed: 1430

Commentary A half-century history of aging research in San Antonio Ganga Tandukar, Lisa C. Flores, Colton Allen, Yuji Ikeno Published: Tuesday, December 30, 2025 Viewed: 1394

Letter to Editor Prevalence of geriatric syndromes in patients with advanced dementia cared for by a Geriatric Home Care Unit Arís Somoano Sierra, Blanca Garmendia Prieto, Francisco Sánchez del Corral Usaola, Javier Gómez Pavón Published: Tuesday, March 31, 2026 Viewed: 1385

Commentary Rethinking morphine for neuropathic pain in the elderly: a neuroimmune perspective on preclinical evidence and clinical caution Shima Hashemi, Bahareh Lashtoo Aghaee, Samaneh Farrokhfar Published: Tuesday, March 31, 2026 Viewed: 1342

Editorial Geropathology is a common denominator for multispecies research in geroscience, from insects to nonhuman primates Jenna Klug, Warren Ladiges Published: Tuesday, March 31, 2026 Viewed: 1310

Research Article Neuroprotective effect of aldehyde trapping agent, hydralazine, in a Parkinson’s disease mouse model Elizabeth Fernandez, Margaret Chia-Ying Wey, Paul Anthony Martinez, Patricia Sullivan, David Goldstein, Randy Strong Published: Tuesday, March 31, 2026 Viewed: 1259

Reviewer Acknowledgement 2025 Reviewer Acknowledgment editor apt Published: Tuesday, December 30, 2025 Viewed: 1075

Research Article Sensory reweighting patterns and fall history in early geriatric age: implications for physiotherapy assessment Wittaya Duangnga Published: Tuesday, June 30, 2026 Viewed: 1058

Review Senotherapeutic potential of Mediterranean diet-derived bioactives in healthy aging and frailty Sedat Arslan Published: Tuesday, June 30, 2026 Viewed: 1027

Review Role of miR-140-5p in vascular aging and arterial stiffening: a review of potential mechanisms Muhammad Iqhrammullah, Ayers GI Kalaij, Vindasya Almeira, Febi Septiani, Priscilla CNBR Sirait, I Made Dwi Mertha Adnyana, Keviano Bobby, Sania Zahrani, Derren DCH Rampengan Published: Tuesday, June 30, 2026 Viewed: 910

Research Article Genetic drift and selective pressures shaping mitochondrial ND3 variants m.10398A>G and m.10400C>T: implications for type 2 diabetes risk in Indian population Jwalant Waghmare, Tejas Tajane, Mamata Chandrakar, Prafulla Ambulkar, Pranita Waghmare, Bharati Taksande Published: Tuesday, June 30, 2026 Viewed: 887

Research Article Approximate prediction of life expectancy in the older people using a revised equation for estimating somatic telomere length from clinical blood data Toyoki Maeda Published: Tuesday, June 30, 2026 Viewed: 872

Editorial Disrupted calcium homeostasis: a hidden driver of cellular aging Patricia Pantoja Newman, Brandt D. Pence Published: Tuesday, June 30, 2026 Viewed: 867

Editorial Brain iron in ageing: Pixels to pathways Thomas Welton Published: Tuesday, June 30, 2026 Viewed: 836

Letter to Editor Low-dose radiotherapy for severe osteoarthritis refractory to conservative treatment in older adults: an underexplored option Jorge Andrés Sánchez Duque, María Camila Fernández-Gualdron, Miguel M Moreno-Capacho, Holman Duvan Ballesteros-Gomez Published: Tuesday, June 30, 2026 Viewed: 821

Mini Review Countering oxysterol-driven neurodegeneration: diosgenin as a privileged steroidal scaffold for novel Alzheimer’s disease therapeutics Sarvesh Sabarathinam Published: Tuesday, June 30, 2026 Viewed: 817

Commentary Targeting ageing: the next frontier in drug delivery systems Rajaram Mohapatra, Pratikeswar Panda Published: Tuesday, June 30, 2026 Viewed: 790

Therapeutic Brief Voluntary wheel running enhances neuronal BDNF in very old C57BL/6 mice Gina Israel, Ruby Sue Mangalindan, Warren C Ladiges, Addison Keely Published: Tuesday, June 30, 2026 Viewed: 767

Commentary The association of post-traumatic stress disorder with accelerated aging Anton R. Kiselev Published: Tuesday, June 30, 2026 Viewed: 707

Review Neuroinflammation across neurodegenerative diseases: an aging-conditioned convergence–divergence framework for precision neuroimmunology Mohammad Harun-Ur-Rashid, Israt Jahan Published: Thursday, August 27, 2026 Viewed: 252

Review Neuroinflammation in diabetes: from pathophysiological mechanisms to therapeutic opportunities Alma Karen Lomeli-Lepe, Dulce Elena Silva-Silverio, Mónica Elisa Ureña-Guerrero, Silvia Josefina López-Pérez Published: Tuesday, August 25, 2026 Viewed: 244

Commentary The cricket brain: a tractable system for decoding neural aging Gerald Yu Liao, Ariana Rhim, Jackson Wezeman, Warren Ladiges Published: Thursday, September 10, 2026 Viewed: 215

Review Neuroinflammation and humoral immunity across chronic diseases: mechanisms, biomarkers, and therapeutic implications Lidija Radenovic Published: Wednesday, September 30, 2026 Viewed: 195

Commentary Aging and memory: a personal perspective Fergus Craik Published: Thursday, August 27, 2026 Viewed: 188

Research Article Development of an organotypic brain slice culture model for testing resilience to aging using tissues collected from geriatric mice Addison Keely, Jackson Wezeman, Savanna Roberts, Sonali Bhana, Warren Ladiges Published: Thursday, September 10, 2026 Viewed: 169

Commentary Rethinking sarcopenia screening in middle age—The 2025 AWGS consensus and its implications for cognitive health Chieh Chen, Da-Ming Liao Published: Friday, August 28, 2026 Viewed: 167

Review Molecular and cellular mechanisms underlying Alzheimer’s disease: an integrated review Mohammad Faraz Tavili, Hussein A. Ghanimi, Arash Abdolmaleki, Maedeh Naghizadeh Published: Thursday, September 10, 2026 Viewed: 166

Review Development of dietary supplements to eliminate the atherogenicity of low-density lipoprotein Tatyana Ivanovna Kovyanova, Vasily Petrovich Karagodin, Daria Dmitryevna Borodko, Ulyana Vyacheslavovna Rozhkova, Stanislav Anatolievich Antonov, Aleksandra Sergeevna Utkina, Galina Alexandrovna Chizhikova Published: Friday, September 11, 2026 Viewed: 153

Research Article Deciphering the action of indole analogues on selected targets for neuroprotection in Alzheimer’s disease. Network pharmacology, in silico, and in vitro approaches Manas Kumar Gedla, Ramanathan Muthiah Published: Wednesday, September 30, 2026 Viewed: 93

Commentary Sarcopenia beyond muscle: a public health challenge Maria Júlia dos Reis Caetano, Letícia Victória Silva Santos, Gerlane Henriques dos Santos, Ester de Sousa Andrade, Mateus Yan Tavares Aragão, Pedro Henrique Fidelis Barboza, Jarbelle Gomes da Silva, Thamyres Andressa Feitosa Medeiros, Weslley Barbosa Sales Published: Thursday, September 24, 2026 Viewed: 52

Review Unveiling the gut-muscle-adipose axis in sarcopenic obesity: mechanisms of inter-organ crosstalk and perspectives on GLP-1-based therapeutics Sarvesh Sabarathinam, Akshaya Krishnan, Venkatalakshmi Ranganathan, Nila Ganamurali, Prathiba Varadhan Published: Wednesday, September 30, 2026 Viewed: 44

Review Pathogenesis and pathobiology of imaging vascular biomarkers during the aging process: a narrative review Dušan Petrović Published: Wednesday, September 30, 2026 Viewed: 41

Aging Pathobiology and Therapeutics

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Aging Pathobiology and Therapeutics

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THE ANT JOURNALS

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