• 环境可持续性成为企业社会责任的重要组成部分。
  • 健康的生活方式是预防疾病的最佳方式。
  • 大数据和机器学习在商业决策中的作用越来越重要。
  • 电子商务的增长正在改变全球零售业的格局。
  • 可持续发展目标正在推动全球经济的绿色转型。
  • 太空探索技术的进步为人类带来了新的可能。
  • 农业科技的进步正在提高粮食生产效率。
  • 在线健身和虚拟健身课程在疫情期间迅速流行。
  • 电子竞技的流行正在改变体育和娱乐行业的格局。
  • 生物技术在医药领域的应用为治疗复杂疾病提供了新的可能性。
  • 海洋塑料污染问题引起了全球范围内的环保行动。
  • 电动汽车的普及推动了能源行业的转型,减少了对化石燃料的依赖。
  • 数据隐私和网络安全成为数字化时代的重要议题。
  • 虚拟现实和增强现实技术在娱乐和教育领域的应用前景广阔。
  • 隐私保护和数据安全成为数字时代的重要议题。
  • 虚拟现实技术在游戏和教育领域的应用越来越广泛。
  • 随着太空探索的进展,商业航天领域迎来了新的发展机遇。
  • 生物多样性的丧失引起了全球对自然保护的重视。
  • 全球健康危机促使各国加强公共卫生体系的建设和改革。
  • 生物多样性的丧失引起了全球对生态环境保护的重视。
  • 智能家居设备的发展正在引领家庭生活向更智能、更环保的方向发展。
  • 随着移动支付的普及,现金交易正在逐渐减少。
  • 在线健身和虚拟健身课程在疫情期间迅速流行。
  • 生物技术的进步为治疗遗传疾病提供了新的可能性。
  • 在线教育的普及为全球学习者提供了更多样化的学习资源。
  • Finding prodromal frailty in a community-dwelling healthy older cohort by survey of BDNF or hand grip strength classified by BMI | Hachisu | Aging Pathobiology and Therapeutics

    Finding prodromal frailty in a community-dwelling healthy older cohort by survey of BDNF or hand grip strength classified by BMI

    Mitsugu Hachisu, Masahiro Hashizume, Hisashi Kawai, Motonaga Kojima, Yoshinori Fujiwara, Shuichi Obuchi, Mari Kogo, Masayuki Ohbayashi, Noriko Koyama, Miki Takenaka, Kazushige Ihara

    Abstract


    Introduction: Brain-derived neurotrophic factor (BDNF) which is involved in neurogenesis, phenotypic differentiation, and neuronal survival is gaining traction in the field of gerontology research as a relevant factor in cognition and vitality in the older population. Frailty which is losing body weight or lean body mass, experiencing fatigue and loss of strength or endurance, may easily fall and fracture bones, thus becoming hospitalized and bedridden. We studied a distribution of mean BDNF levels or hand grip strengths in the classified BMI, and found the lowest BMI class of thin category has significantly (p<0.01) lower mean BDNF level or mean hand grip strength than in the normal or obese 1 category of BMI.  Therefore we defined the lowest BMI category “thin” as “prodromal frailty”, but not pre-frailty. We will report the findings of “prodromal frailty” and discuss how to prevent this stage from advancing to frailty.

    Methods: We measured serum BDNF concentrations, BMI and various health parameters in 805 elderly (aged 65–84) regional health examination participants from the Tokyo area. Their serum BDNF levels and grip strengths were divided according to BMI classification.

    Results: The mean serum BDNF levels increased linearly according to BMI categorization from thin (<18.4 kg/m2) to obese2 (30–34.9 kg/m2) and decreased in the obese3 group (35–39.9 kg/m2). The mean serum BDNF level in the thin category was significantly lower than that in the normal category (p<0.01). The BDNF levels in the obese1 and obese2 categories did not differ significantly from that in the normal category. Mean hand grip strength (kg) was also similarly distributed to the mean BDNF level distribution in the classified BMIs.

    Conclusions: Elderly people in the thin BMI category had significantly lower serum BDNF levels and weaker hand grip strength than those in the normal or slightly obese categories and the people in this category is so called “prodromal frailty” but not pre-frailty.

    Keywords: Frailty, body mass index, brain-derived neurotrophic factor, health examination, hand grip strength




    Subscribe to receive issue release notifications
    and newsletters from journals