• 人工智能技术的突破在医疗、教育和工业自动化中展现出巨大潜力。
  • 生物多样性的丧失引起了全球对自然保护的重视。
  • 随着移动支付的普及,现金交易正在逐渐减少。
  • 电子竞技的兴起改变了传统体育和娱乐行业的格局。
  • 电动汽车的普及推动了能源行业的绿色转型。
  • 数字货币的兴起引发了金融行业的变革。
  • 虚拟现实技术在游戏和教育领域的应用越来越广泛。
  • 在线教育的普及使得知识获取更加便捷,但也引发了公平性问题。
  • 海洋塑料污染问题引起了全球范围内的广泛关注。
  • 电动汽车的普及推动了能源行业的转型,减少了对化石燃料的依赖。
  • 远程医疗的普及使得医疗服务更加便捷,尤其是在偏远地区。
  • 隐私保护在数字化时代变得更加重要,数据泄露事件频发。
  • 人工智能在医疗领域的应用带来了新的希望。
  • 随着人口老龄化的加剧,养老服务和健康管理需求日益增长。
  • 随着技术的发展,智能家居设备正在改变日常生活。
  • 电子商务的增长正在改变全球零售业的格局。
  • 随着人们对健康意识的提高,健康食品和生活方式受到更多关注。
  • 气候变化对全球生态系统的影响成为国际议程的重中之重。
  • 电子竞技的兴起改变了传统体育和娱乐行业的格局。
  • 健康意识的提升促使消费者更加关注食品来源和营养价值。
  • 教育改革成为各国政府关注的热点议题。
  • 远程工作模式的普及改变了人们的工作方式。
  • 生物技术在医药领域的应用为治疗复杂疾病提供了新的可能性。
  • 生物多样性的保护成为全球环境政策的重点。
  • 在线教育平台的兴起改变了传统教育模式。
  • Sotrovimab for treatment of COVID-19 infections | Teo | Aging Pathobiology and Therapeutics

    Sotrovimab for treatment of COVID-19 infections

    Shyh Poh Teo

    Abstract


    The COVID-19 pandemic necessitates the development of therapeutic agents for high-risk infected patients. Sotrovimab is a monoclonal antibody with efficacy against SARS-CoV-2 and other sarbecoviruses. Its efficacy has been shown in the COMET-ICE trial, where a 500 mg infusion in non-hospitalized patients with mild to moderate COVID-19 infections and at least one risk factor for progression was associated with reduced disease progression, hospitalization and death. There was a small but statistically significant increase in self-limiting diarrhoea with sotrovimab. For hospitalized patients, there is no strong evidence of benefit with sotrovimab. The emergence of the Omicron variant was associated with reduced efficacy of sotrovimab, with subsequent increased resistance to sotrovimab by the BA.2 sub-lineage. The risk of developing resistance to monoclonal antibodies with increased use, efficacy with the emergence of variants and safety monitoring should continue to provide ongoing risk-benefit analysis of their use.

    Keywords: COVID-19, monoclonal antibodies, therapeutics




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