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  • 在线健身和虚拟健身课程的兴起反映了人们对健康生活方式的追求。
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  • 隐私保护和数据安全成为数字时代的重要议题。
  • 气候变化对全球生态系统的影响成为国际议程的重中之重。
  • 全球健康危机凸显了加强公共卫生体系和国际卫生合作的紧迫性。
  • 随着生物技术的进步,疾病治疗和健康管理带来了新的希望。
  • 海洋塑料污染问题引起了全球范围内的环保行动。
  • 太空探索的商业化为航天行业带来了新的机遇。
  • 人工智能在各个行业的应用正推动着生产力的革命。
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  • 随着城市化的加速,城市可持续发展和智能城市规划成为热点议题。
  • Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice | Nickel | Aging Pathobiology and Therapeutics

    Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice

    Kaitlin Nickel, Lida Zhu, Ruby Mangalindan, Jessica M. Snyder, Matthew Tucker, Jeremy Whitson, Maryia Sweetwyne, Ana P. Valencia, Jenna Klug, Zhou Jiang, David J. Marcinek, Peter Rabinovitch, Warren Ladiges

    Abstract


    Disruption of metabolic and bioenergetic homeostasis related to mitochondrial dysfunction is a key driver of aging biology. Therefore, targeting mitochondrial function would be a rational approach to slowing aging. Elamipretide (Elam, a.k.a. SS-31) is a peptide known to target mitochondria and suppress mammalian signs of aging. The present study was designed to examine the phenotypic effects of long-term Elam treatment on aging in C57BL/6 mice starting at 18 months of age. Mice were fed regular chow (RC diet) or a diet high in fat and sugar (HF diet) and treated with 3 mg/kg of Elam or saline subcutaneously 5 days per week for 10 months. Physiological performance assessments were conducted at 28 months of age. Elam improved the physical performance of males but not females, while in females Elam improved cognitive performance and enhanced the maintenance of body weight and fat mass. It also improved diastolic function in both males and females, but to a greater extent in males. The HF diet over 10 months had a negative effect on health span, as it increased body fat and decreased muscle strength and heart function, especially in females. In conclusion, Elam enhanced healthy aging and cardiac function in both male and female mice, although the specific effects on function differed between sexes. In females, the treatment led to better cognitive performance and maintenance of body composition, while in males, performance on a rotating rod was preserved. These overall observations have translational implications for considering additional studies using Elam in therapeutic or preventive approaches for aging and age-related diseases.

    Keywords: Aging, mitochondria, elamipretide, C57BL/6 mice, high fat and sugar diet




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