• 数字化转型正在改变企业的运营模式,特别是零售和服务业。
  • 智能家居设备使日常生活更加便捷,推动了居住环境的智能化。
  • 社交媒体对政治选举的影响力日益显著。
  • 全球范围内的疫苗接种运动正在加速,为控制疫情带来希望。
  • 电动汽车的快速增长正在推动传统汽车行业的转型。
  • 电动汽车的快速增长正在推动传统汽车行业的转型。
  • 随着全球化的深入,多语言能力和跨文化交流变得日益重要。
  • 海洋塑料污染问题引起了全球范围内的环保行动。
  • 随着人们对健康意识的提高,健康食品和生活方式受到更多关注。
  • 电动汽车市场的快速增长推动了全球能源结构的转型。
  • 随着全球经济不确定性增加,跨国公司的社会责任和环境影响受到更多审视。
  • 虚拟现实和增强现实技术在教育和娱乐领域的应用越来越广泛。
  • 生物多样性的丧失引起了全球对自然保护的重视。
  • 在线教育平台的兴起挑战了传统教育模式和学习习惯。
  • 云计算的普及正在改变企业的IT基础设施和运营模式。
  • 自动化和机器人技术在提高制造业效率和安全性方面发挥着关键作用。
  • 智能家居设备的发展正在改变人们的生活方式。
  • 随着环保意识的提高,可持续消费和绿色生活方式成为新的消费趋势。
  • 人工智能技术的融合正在推动医疗、工业和服务业的创新。
  • 随着全球健康危机的持续,公共卫生体系的完善成为紧迫议题。
  • 数字货币的兴起引发了金融行业的变革。
  • 移动支付的普及改变了人们的支付习惯。
  • 大数据和人工智能在商业分析和决策中的重要性日益增加。
  • 智能家居设备的发展正在改变人们的生活方式。
  • 生物多样性的丧失引起了全球对自然保护的重视。
  • Serum elementomic analysis indicates a panel of elements related with age | Jia | Aging Pathobiology and Therapeutics

    Serum elementomic analysis indicates a panel of elements related with age

    Kai-Yue Jia, Hui-Xian Sun, Yan-Ru Li, Can Zhao, Xiang Lu, Wei Gao

    Abstract


    Background: Elementomics, which includes metallic and non-metallic elements, is an emerging and promising research field for human diseases. Researchers are focusing on discovering the relationship between elements and various diseases; however, the changes in element concentrations during the process of aging remain unclear.

    Materials and Methods: We performed elementomic analysis in the serum of 70 subjects aged 30 to 96 years using inductively coupled plasma mass spectrometry. The subjects were divided into 7 groups with an age range of 10 years. Random forest was used to estimate the variable importance of elements. Linear regression model and restricted cubic spline analysis were performed to screen for elements individually associated with age. Candidate elements were combined by corresponding multivariate linear regression coefficients to generate a risk score representing their collective effect on age.

    Results: Among the 62 detected elements, lithium, boron, calcium, titanium, and selenium were identified as the most important predictors of age. There was an increase in lithium and boron as well as a decrease in calcium and titanium with increasing age. The concentration of selenium was elevated before the age of 60, but decreased thereafter. A formula of element risk score was constructed using the respective coefficients from a multivariate linear regression model for the above five elements. The formula = 4.5522 × lithium + 6.0575 × boron - 4.9990 × calcium - 7.0403 × titanium - 0.8849 × selenium.

    Conclusion: Elementomics could be a novel and promising non-invasive biomarker for the assessment of senescence.

    Keywords: Elementomics, serum, age, inductively coupled plasma mass spectrometry




    Subscribe to receive issue release notifications
    and newsletters from journals